What is OptiImmuno +?
It is a careful selection of functional ingredients that have proven to provide health benefits, helping the body to function correctly, lead a healthier lifestyle and increase life expectancy.
What functional ingredients make it up and to what do they contribute?
- The alga Ascophyllum nodosum, is an alga from the North Atlantic Ocean, where it grows on the rocky shores of the coasts and estuaries. It is grown in Ireland, Scotland and Norway for its content in phlorotannins and alginic acid, as well as being rich in other organic acids, polysaccharides, amino acids, and proteins. The daily intake of this alga has been shown to reduce the formation of supragingival stones and tartar, improving the health of teeth and gums.
- Salmon oil and flaxseed are natural sources of omega 3 and 6, a group of long-chain polyunsaturated fatty acids. Omega 3 fatty acids include α-linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and omega 6, linoleic acid, γ-linolenic acid and arachidonic acid. Except for arachidonic acid, the rest are essential fatty acids for the dog, that is, it can not be synthesized in your body and must be taken from the diet.
Omega 3 fatty acids are necessary for brain function and the retina, while omega 6 is essential for growth, reproduction and as precursors of the synthesis of prostaglandins (cellular mediators essential for the proper functioning of the nervous system, cardiovascular, reproductive and digestive). Both contribute to the fluidity of cell membranes and the health of the skin and hair, which act as a barrier against environmental pathogens.
The benefits of ingesting omega 3 and 6, taking into account that many of them are essential, are well known, and among them, its effect on skin health, osteoarthritis, liver problems, cardiovascular, cognitive function stand out and even some types of cancer. Despite its benefits, it must also be borne in mind that excess is as dangerous as its lack, so extra supplementation without veterinary prescription is not recommended. Ideally, look for a formulated food that contains the amounts necessary to ensure adequate intake of omega 3 and 6. The recommendations for omega 3 and 6 in dogs are:
|Recommended||ERA Puppy Small breeds||ERA Puppy Medium breeds||ERA Puppy Large breeds|
|Omega 6||minimum 1.3%||2.9%||2.6%||2%|
|Omega 3||minimum 0.13%||0.35%||0.3%||0.25%|
|Recommeded||ERA Adult Small breeds Chicken & Pheasant||ERA Adult Medium & Large breeds Chicken & Pheasant||ERA Adult Small breeds Duck & Lamb||ERA Adult Medium & Large breeds Duck & Lamb||ERA Adult Small breeds Salmon & Herring||ERA Adult Medium & Large breeds Salmon & Herring|
|Omega 6||minimum 1.32%||2.3%||1.7%||1.8%||1.8%||2%||1.8%|
|Omega 3||minimum 0.05%||0.25%||0.25%||0.45%||0.45%||0.7%||0.6%|
- Plants and extracts, in addition to some fruits and vegetables, are natural sources of polyphenols (bioflavonoids) and carotenoids. Highlights include citrus extract, apple pulp, red fruits (blueberries and pomegranate), some vegetables (spinach, pumpkin, and tomato), and plant extracts (thyme, rosemary, and calendula).
Polyphenols and carotenoids are a very broad group of substances produced naturally by plants, with a function of protection against UV light and oxidation due to the formation of free radicals, against herbivorous animals (some, such as tannins) , give a bitter taste) or as a claim to attract pollinating animals or dispersers of seeds and fruits (give colors and specific aromas to attract such animals). Animals are not able to produce these substances, so they must obtain them from the diet by ingesting the plants that produce them. In the animals that ingest those plants, they have antioxidant action, are precursors of vitamins and have a protective effect against coronary, cerebrovascular, neurodegenerative diseases and some types of cancer.
Some of the best-known bioflavonoids are quercetin, silymarin, anthocyanidins, and tannins; and within the carotenoids, the β-carotene, precursor of vitamin A.
- Glucosamine, chondroitin sulfate and green-lipped mussel have been shown to be helpful in joint problems, especially osteoarthritis. Glucosamine is an amino sugar that acts as a precursor in the formation of glycosaminoglycans and is in large quantities in the shell of crustaceans, from where it is extracted. Chondroitin sulfate is the major glycosaminoglycan in the composition of connective tissues (cartilage, ligaments, and tendons) providing elasticity and resistance to compression. For its part, the green-lipped mussel (Perna canaliculus) is a mussel native to the coast of New Zealand and a staple in the diet of the Maori culture, with anti-inflammatory action due to its content of polyunsaturated fatty acids.
- The chicory root, brewer’s yeast and Enterococcus faecium act at the intestinal level favoring the establishment of an adequate intestinal microbiota. The chicory is a plant native to the Mediterranean area whose root is rich in inulin and fructooligosaccharides (FOS), and brewer’s yeast (Saccharomyces cerevisiae) is a unicellular fungus that has been used traditionally in the manufacture of beer and bread for its ability to ferment sugars. In ERA we use dry yeast, without capacity for fermentation of sugar, because its cell wall is very rich in mananooligosaccharides (MOS). Both inulin and FOS and MOS are prebiotics, non-digestible foods that benefit intestinal health by selectively stimulating the growth of “friendly” intestinal bacteria. These bacteria are part of the healthy microbiota of the intestine; they occupy the intestinal niche, preventing the establishment of pathogenic bacteria and producing vitamins and short-chain volatile fatty acids that can be absorbed in the large intestine. On the other hand, Enterococcus faecium, specifically its strain DSM 10663 / NCIMB 10415, is one of those “friendly” bacteria that acts as a probiotic, that is, is a living microorganism that remains active in the intestine and is able to colonize it and, in this way, displaces pathogenic bacteria that could cause an intestinal infection (such as Salmonella, Clostridium or Escherichia coli).
Both (pre and probiotic) act together, enhancing their effects (symbiotic).
- ERA is enriched with vitamins and minerals, which ensure optimal daily intake of these micronutrients. Among them we find:
- Vitamin A: is a fat-soluble vitamin essential for the development of vision, growth and differentiation of the epithelial tissue of the respiratory and digestive systems.
- Vitamin E: is a fat-soluble vitamin that acts as an antioxidant and is essential for the reproduction and health of the nervous system.
- Group B vitamins: are water-soluble vitamins related to cell metabolism, in which they have essential roles in energy metabolism, DNA repair and enzymatic activity. Some of them also play an important role in the development of the nervous system or the proper functioning of the blood and the immune system.
- Zinc: essential mineral in the metabolism, contributes to the proper functioning of the immune system, the nervous system and the healing of wounds.
- Selenium: is a micronutrient that acts as an antioxidant, helps neutralize free radicals, stimulates the immune system and participates in the functioning of the thyroid gland.
All the benefits of ERA ingredients are based on scientific studies, namely:
* The alga Ascophyllum nodosum:
- Silver-Zeolite Combined to Polyphenol-Rich Extracts of Ascophyllum nodosum: Potential Active Role in Prevention of Periodontal Diseases.
- A randomized controlled clinical study of the effect of daily intake of Ascophyllum nodosum alga on calculus, plaque, and gingivitis
*Salmon oil and flaxseed:
- Omega 3 – Omega 6: What is right for the liver?
- Beneficial effects of omega-3 fatty acids in cardiovascular disease.
- Dose-tritation effects of fish oil in osteoarthritic dogs.
- Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work?
- Papel de los ácidos grasos omega-3 en la prevención de enfermedades cardiovasculares.
- Analysis of epidermal lipids in normal and atopic dogs, before and after administration of an oral omega-6/omega-3 fatty acid feed supplement. A pilot study.
* Plants and extracts, in addition to some fruits and vegetables:
- Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet.
- Quercetin: a versatile flavonoid.
- Effects and synergy of feed ingredients on canine neoplastic cell proliferation.
- Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs.
- The Effect of Calendula Officinalis in Therapy of Acetic Acid Induced Ulcerative Colitis in Dog as an Animal Model.
- Carotenoids: biochemistry, pharmacology and treatment.
- Antimicrobial effect of the essential oil from Rosmarinus officinalis L. against Staphylococcus pseudintermedius isolated from dogs.
- Hepato and reno protective action of Calendula officinalis L. flower extract.
- Potential renoprotective effects of silymarin against nephrotoxic drugs: a review of literature.
* Glucosamine, chondroitin sulfate and green-lipped mussel
- Green-lipped mussel extract (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study.
- Ramdomised doublé-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis.
- Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus.
* The chicory root, brewer’s yeast and Enterococcus faecium
- Dietetic combination of mannan-oligosaccharides and fructooligosaccharides modifies nitrogen metabolism in dogs.
- Beneficial aspects of inulin supplementation as a fructooligosaccharide prebiotic in monogastric animal nutrition – A review.
- Efectos clínicos de los probióticos: qué dice la evidencia.
- The utilisation of prebiotics and synbiotics in dogs.
- Efficacy of a Probiotic-Prebiotic Supplement on Incidence of Diarrhea in a Dog Shelter: A Randomized, Double-Blind, Placebo-Controlled Trial
- Stimulation of Duodenal Biopsies and Whole Blood from Dogs with Food-Responsive Chronic Enteropathy and Healthy Dogs with Toll-Like Receptor Ligands and Probiotic Enterococcus faecium.
- Mechanisms of the effects of probiotics on symbiotic digestion.
* ERA is enriched with vitamins and minerals,
- Management of zinc responsive dermatitis in dogs.
- Combs, G.F. & McClung, J.P. (eds) The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier (2017) 5th edition. London. ISBN: 978-0-12-802965-7.
- Effect of Selenium and Vitamin E Supplementation on Semen Quality in Dogs with Lowered Fertility.
- Comparison of Standard Protocols for the Treatment of Canine Leishmaniasis in an Endemic Area with and Without Zinc Oral Supplementation.